Liver biopsies were graded for the presence of fat, inflammation, and fibrosis on a scale from 0 to 3. Serum total homocyteine, folate and vitamin B12 concentrations and hepatic enzymes were measured. We investigated whether there is an association between serum folate and total homocysteine concentrations with the presence of non-alcoholic fatty liver disease (NAFLD) in obese subjects.Forty-three obese (body mass index ≥35 kg/m2) patients who underwent bariatric surgery and hepatic biopsy were included. In addition, some investigators have reported an inverse association between serum folate and body mass index and a positive correlation between total homocysteine and fat mass. Folate depletion and hyperhomocysteinemia increase the risk for hepatic alcoholic damage and promote oxidative stress in animals.
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